The most persistent adverse effect is retrograde amnesia. THE COGNITIVE adverse effects of electroconvulsive therapy (ECT) limit its use. Bilateral ECT produces more profound amnestic effects than RUL ECT, particularly for memory of impersonal events. At the 2-month follow-up, patients had reduced retrograde amnesia, but continued to show deficits in recalling the occurrence of impersonal events and the details of recent impersonal events.Ĭonclusions The amnestic effects of ECT are greatest and most persistent for knowledge about the world (impersonal memory) compared with knowledge about the self (personal memory), for recent compared with distinctly remote events, and for less salient events. These effects were independent of electrical dosage and clinical outcome. Bilateral ECT caused more marked amnesia for events and details than RUL ECT, and especially for impersonal memories. Results Shortly after ECT, patients recalled fewer events and event details than controls, with the deficits most marked for impersonal compared with personal events. Normal controls were tested at matched intervals. The Personal and Impersonal Memory Test was administered by blinded raters at baseline, during the week after ECT, and at the 2-month follow-up. Methods Fifty-five patients with major depression were randomly assigned to right unilateral (RUL) or bilateral (BL) ECT, each at either low or high electrical dosage. This study examined the short- and long-term effects of differing forms of ECT on memory of personal and impersonal (public) events.
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